Neonates exposed to Sertraline hydrochloride and other SSRIs or serotonin and norepinephrine reuptake inhibitors SNRIs late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding. Such complications can arise immediately upon delivery. Reported clinical findings have included respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor, jitteriness, irritability, and constant crying. These features are consistent with either a direct toxic effect of SSRIs and SNRIs or, possibly, a drug discontinuation syndrome.
Lazowick AL, Levin GM. Potential withdrawal syndrome associated with SSRI discontinuation. Ann Pharmacother. What are the possible side effects of Warfarin sodium tablets? CYP450 enzymes, other drug interactions. a For most patients, an SSRI, SNRI, mirtazapine, or bupropion is considered optimal.
Panic disorder: Treatment of panic disorder in adults with or without agoraphobia. Settle EC Jr. Akathisia and sertraline. J Clin Psychiatry. Andrade SE, McPhillips H, Loren D et al. Antidepressant medication use and risk of persistent pulmonary hypertension of the newborn. Pharmacoepidemiol Drug Saf.
Global Impressions and Self-Rating Symptom Scale. Walinder J, Skott A, Carlsson A, et al. Potentiation of the antidepressant action of clomipramine by tryptophan. Sertraline hydrochloride has not been evaluated in patients with a seizure disorder. These patients were excluded from clinical studies during the product's premarket testing. No seizures were observed among approximately 3000 patients treated with Sertraline hydrochloride in the development program for major depressive disorder. It is important to continue taking this medication as prescribed even if you feel well. not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped.
Keep Warfarin sodium tablets in a tightly closed container, and keep Warfarin sodium tablets out of the light. Carefully consider these findings when assessing potential benefits and risks of sertraline for any clinical use. 1 304 305 310 345 See Suicidality in the Boxed Warning and also see Worsening of Depression and Suicidality Risk under Cautions. Anon. In defense of fluoxetine. Int Drug Ther News. Glucosamine: May enhance the antiplatelet effect of Agents with Antiplatelet Properties. Please refer to the for information on shortages of one or more of these preparations. L-tryptophan increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking L-tryptophan with these medications used for depression might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety. The decrease in pup survival was shown to be due to in utero exposure to Sertraline. The clinical significance of these effects is unknown. There are no adequate and well-controlled studies in pregnant women. Sertraline hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregnant women exposed to antidepressants during pregnancy are encouraged to enroll in the National Pregnancy Registry for Antidepressants NPRAD. Women 18 to 45 years of age or their health care providers may contact the registry by calling 844-405-6185. Enrollment should be done as early in pregnancy as possible. This may be gradually increased if needed and tolerated. The elderly may be especially sensitive to the effects of benzodiazepines. If side effects occur at the recommended starting dose, the dose may be lowered. Azilect rasagiline US prescribing information. Teva Neurosciences Inc.
Gupta MA, Gupta AK. Chronic idiopathic urticaria associated with panic disorder: a syndrome responsive to selective serotonin reuptake inhibitor antidepressants. Cutis. Mothers taking an SSRI during pregnancy and postpartum may have difficulty breastfeeding and may require additional breastfeeding support. Zolpidem is excreted in human milk. MiFEPRIStone: May enhance the QTc-prolonging effect of QTc-Prolonging Agents Indeterminate Risk and Risk Modifying. Management: Though the drugs listed here have uncertain QT-prolonging effects, they all have some possible association with QT prolongation and should generally be avoided when possible. Olanzapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Zyprexa. Some required a short stay one to four days in the neonatal intensive care unit. None of these symptoms is thought to cause any long-term harm to the baby. Cody, J. D. Metabolic Precursors to Amphetamine and Methamphetamine. Animal studies have failed to reveal evidence of teratogenicity; however, there was evidence of delayed ossification and effects on reproduction attributed to maternal toxicity. Decreased neonatal survival following maternal administration at exposures similar to or slightly greater than the maximum recommended human dose of 200 mg was also observed; the clinical significance is unknown. There are no controlled data in human pregnancy. Medicines used in anaesthesia or to treat chronic pain fentanyl. Etzel KR, Stockstill JW, Rugh JD. Tryptophan supplementation for nocturnal bruxism: report of negative results. Franchini L, Gasperini M, Perez J et al. A double-blind study of long-term treatment with sertraline or fluvoxamine for prevention of highly recurrent unipolar depression. J Clin Psychiatry. Antidepressants SSRIs such as fluoxetine for example, Prozac and are commonly prescribed to treat OCD. These medicines are taken as tablets or capsules. The medicine can also help symptoms of OCD. The tricyclic antidepressant clomipramine is sometimes used as well. The amount of flecainide in your blood may increase and cause more side effects than normal. Szabo CP. Fluoxetine and sumatriptan: possibly a counterproductive combination. J Clin Psychiatry. Alprazolam is discontinued. These are generally minor but seizure can occur, especially if you reduce the dose too rapidly or discontinue the medication abruptly. Seizure can be life-threatening. Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to Toradol. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen. nimotop
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. CYP3A inducers would be expected to decrease Alprazolam concentrations and this has been observed in vivo. Possible complications, sometimes severe and requiring prolonged hospitalization, respiratory support, enteral nutrition, and other forms of supportive care, reported in neonates exposed to sertraline, other SSRIs, or SNRIs late in the third trimester; may arise immediately upon delivery. 1 301 302 314 315 316 317 318 See General under Dosage and Administration. Some phenothiazines include chlorpromazine Thorazine fluphenazine Prolixin trifluoperazine Stelazine thioridazine Mellaril and others. Since Sertraline hydrochloride is extensively metabolized, excretion of unchanged drug in urine is a minor route of elimination. A clinical study comparing Sertraline pharmacokinetics in healthy volunteers to that in patients with renal impairment ranging from mild to severe requiring dialysis indicated that the pharmacokinetics and protein binding are unaffected by renal disease. The treatment of excessive anticoagulation is based on the level of the INR, the presence or absence of bleeding, and clinical circumstances. Lyketsos CG, DelCampo L, Steinberg M et al. Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS. Arch Gen Psychiatry. Atenolol- Sertraline hydrochloride 100 mg when administered to 10 healthy male subjects had no effect on the beta-adrenergic blocking ability of atenolol. These lesions did not appear until after 11 months of treatment. It is not known whether, and if so in what amount, Sertraline or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Sertraline hydrochloride is administered to a nursing woman. Berh CA, Doogan DP. Sudden chest pain with sertraline. Lancet. onneto.info aciphex
However, suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide. Shapiro S. L-tryptophan and eosinophilia-myalgia syndrome. The following factors may be responsible for increased INR response: diarrhea, hepatic disorders, poor nutritional state, steatorrhea, or vitamin K deficiency. Dalton SO, Johansen C, Mellemkjaer L et al. Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study. Arch Intern Med. Clark DB, Andrus MR, Byrd DC. Drug interactions between linezolid and selective serotonin reuptake inhibitors: case report involving sertraline and review of the literature. Pharmacotherapy. Goldberg RJ. Selective serotonin reuptake inhibitors: infrequent medical adverse effects. Arch Fam Med.
Sertraline hydrochloride tablets for the treatment of these indications. Consequently, a dose of 50 mg, administered once daily, is recommended as the initial therapeutic dose. Brown DF, Kerr HD. Sertraline overdose. Ann Pharmacother. Reynolds RD. Serotonin syndrome: what family physicians need to know. Am Fam Physician. Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms. Polysorbate 80: Some dosage forms may contain polysorbate 80 also known as Tweens. Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals Isaksson 2002; Lucente 2000; Shelley 1995. Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 Alade 1986; CDC 1984. See manufacturer's labeling. S2” on one side and breakline on other side. Bleeding risk: May impair platelet aggregation resulting in increased risk of bleeding events, particularly if used concomitantly with aspirin, NSAIDs, warfarin or other anticoagulants. Bleeding related to SSRI use has been reported to range from relatively minor bruising and epistaxis to life-threatening hemorrhage. What happens if I miss a dose Zoloft? Organization WHO dictionary of preferred terms. Your dose may need to be gradually decreased to reduce side effects. Report any new or worsening symptoms right away. Your doctor may prescribe other medicines if you have other conditions along with OCD. Moderate to severe impairment Child-Pugh class B or C: Use is not recommended. Dextromethorphan: Selective Serotonin Reuptake Inhibitors may enhance the serotonergic effect of Dextromethorphan. Selective Serotonin Reuptake Inhibitors may increase the serum concentration of Dextromethorphan. Management: Avoid the concurrent use of dextromethorphan and SSRIs, particularly fluoxetine and paroxetine, when possible. The risk for this interaction may persist for several weeks following discontinuation of fluoxetine or paroxetine. Teicher MH, Glod C, Cole JO. Emergence of intense suicidal preoccupation during fluoxetine treatment. Am J Psychiatry. Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies; consider risk prior to prescribing. Kurtz DL, Bergstrom RF, Goldberg MJ et al. The effect of sertraline on the pharmacokinetics of desipramine and imipramine. Clin Pharmacol Ther. buy finasteride in new zealand
Sedative medications can affect the nervous system. L-tryptophan can also affect the nervous system. Taking L-tryptophan along with sedative medications can cause serious side effects. Do not take L-tryptophan if you are taking sedative medications. Keep Warfarin sodium tablets and all medicines out of the reach of children. Protonix Package Insert. March 2012. Cmax was significantly higher 43% and Tmax was significantly decreased -53%. Alprazolam and its metabolites are excreted primarily in the urine. The S-enantiomer of Warfarin is mainly metabolized to 7-hydroxyWarfarin by CYP2C9, a polymorphic enzyme. Galantamine: Selective Serotonin Reuptake Inhibitors may decrease the metabolism of Galantamine. Steinberg M, Morin AK. Mild serotonin syndrome associated with concurrent linezolid and fluoxetine. Am J Health-Syst Pharm. American Psychiatric Association APA. Fisch C, Knoebel SB. Electrocardiographic findings in sertraline depression trials. Drug Invest. Watson Laboratories, Inc. Sertraline hydrochloride tablets prescribing information. Corona, CA; 2007 May. The following symptoms, anxiety, agitation, panic attacks, insomnia, irritability, hostility aggressiveness, impulsivity, akathisia psychomotor restlessness hypomania, and mania, have been reported in adult and pediatric patients being treated with antidepressants for major depressive disorder as well as for other indications, both psychiatric and nonpsychiatric. Pentoxifylline: May enhance the antiplatelet effect of Agents with Antiplatelet Properties. Alcohol should be avoided whilst taking Sertraline. What treatments are available for depression? benemid buy online shopping europe
Montgomery SA. Efficacy in long-term treatment of depression. J Clin Psychiatry. 1996; 57Suppl. Elderly people may be at greater risk for this. Table 5 below displays the incidence of sexual side effects reported by at least 2% of patients taking Sertraline hydrochloride in placebo-controlled trials. Since Toradol is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? Votolato NA, Stern S, Caputo RM. Serotonergic antidepressants and urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. Risk of suicidality; importance of patients, family, and caregivers being alert to and immediately reporting emergence of suicidality, worsening depression, or unusual changes in behavior, especially during the first few months of therapy or during periods of dosage adjustment. 304 305 310 601 See Worsening of Depression and Suicidality Risk under Cautions.
Prozac fluoxetine hydrochloride US prescribing information. Panic disorder DSM-IV is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four or more of the following symptoms develop abruptly and reach a peak within 10 minutes: 1 palpitations, pounding heart, or accelerated heart rate; 2 sweating; 3 trembling or shaking; 4 sensations of shortness of breath or smothering; 5 feeling of choking; 6 chest pain or discomfort; 7 nausea or abdominal distress; 8 feeling dizzy, unsteady, lightheaded, or faint; 9 derealization feelings of unreality or depersonalization being detached from oneself; 10 fear of losing control; 11 fear of dying; 12 paresthesias numbness or tingling sensations; 13 chills or hot flushes. MAO A confirms a theoretical prediction. Leonard BE. Pharmacological differences of serotonin reuptake inhibitors and possible clinical relevance. Drugs. 1992; 43Suppl. How should I take Zyprexa? Sertraline hydrochloride administered daily throughout the menstrual cycle was significantly more effective than placebo on change from baseline to endpoint on the DRSP total score, the HAMD-17 total score, and the CGI-S score, as well as the CGI-I score at endpoint. Dista Products Company. Prozac fluoxetine hydrochloride prescribing information. Indianapolis, IN; 1999 Mar. Evans ML, Kortas KJ. Potential interaction between isoniazid and selective serotonin reuptake inhibitors. Am J Health-Syst Pharm. If Alprazolam tablets are to be combined with other psychotropic agents or anticonvulsant drugs, careful consideration should be given to the pharmacology of the agents to be employed, particularly with compounds which might potentiate the action of benzodiazepines. The benzodiazepines, including Alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol and other drugs which themselves produce CNS depression. Do not use sertraline if you have used an MAO inhibitor such as furazolidone Furoxone isocarboxazid Marplan phenelzine Nardil rasagiline Azilect selegiline Eldepryl, Emsam, Zelapar or tranylcypromine Parnate in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You must wait at least 14 days after stopping an MAO inhibitor before you can take sertraline. After you stop taking sertraline, you must wait at least 14 days before you start taking an MAOI. Nonetheless, at this time, it is recommended that plasma lithium levels be monitored following initiation of Sertraline hydrochloride therapy with appropriate adjustments to the lithium dose. Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency. Crosses the blood-brain barrier. These effects would be expected to be additive to the anticoagulant effects of Warfarin sodium. cozaar can i buy europe
Sanders-Bush E, Mayer SE. 5-Hydroxytryptamine serotonin receptor agonists and antagonists. In: Hardman JG, Limbird LE, Molinoff PB et al, eds. Stock AJ, Kofoed L. Therapeutic interchange of fluoxetine and sertraline: experience in the clinical setting. Am J Hosp Pharm. The anticoagulant effect of Warfarin sodium tablets persists beyond 24 hours. If a patient misses a dose of Warfarin sodium tablets at the intended time of day, the patient should take the dose as soon as possible on the same day. The patient should not double the dose the next day to make up for a missed dose. Ibritumomab. Both agents may contribute to impaired platelet function and an increased risk of bleeding. Necrosis may be associated with local thrombosis and usually appears within a few days of the start of Warfarin sodium therapy. In severe cases of necrosis, treatment through debridement or amputation of the affected tissue, limb, breast, or penis has been reported. Known hypersensitivity to sertraline or any ingredient in the formulation. Effects of concomitant use with ECT have not been systematically evaluated. Patients on oral contraceptives were excluded from these trials; therefore, the efficacy of Sertraline in combination with oral contraceptives for the treatment of PMDD is unknown. Choo V. Paroxetine and extrapyramidal reactions. Lancet. MDD have been conducted with Sertraline hydrochloride, and the data were not sufficient to support a claim for use in pediatric patients. Anyone considering the use of Sertraline hydrochloride in a child or adolescent must balance the potential risks with the clinical need. Females who are pregnant should not handle crushed or broken Warfarin sodium tablets. What are Warfarin sodium tablets? Doogan DP, Caillard V. Sertraline: a new antidepressant. J Clin Psychiatry. If you are taking a combination of drugs, use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. cephalexin
Yonkers KA, Halbreich U, Freeman E et al. Symptomatic improvement of premenstrual dysphoric disorder with sertraline treatment: a randomized controlled trial. JAMA. Taking L-tryptophan with phenothiazines can cause serious side effects including movement disorders. In some rare cases, a drug test may report the presence of illicit or prescription drugs in the immunoassay, although the person has not used these drugs. While this is not common, no test is 100% accurate. Paluck EC, McCormack JP, Ensom MH, Levine M, Soon JA, Fielding DW "Outcomes of bupropion therapy for smoking cessation during routine clinical use. Ensure an adequate airway, oxygenation and ventilation. Monitor cardiac rhythm and vital signs. General supportive and symptomatic measures are also recommended. Induction of emesis is not recommended. Gastric lavage with a large-bore orogastric tube with appropriate airway protection, if needed, may be indicated if performed soon after ingestion, or in symptomatic patients. Fluoxetine: clinical pharmacology and physiologic disposition. Medicines are not always suitable for everyone. The risks, if any, that may be associated with Sertraline hydrochloride's use beyond 1 year in children and adolescents with OCD or major depressive disorder have not been systematically assessed. The prescriber should be mindful that the evidence relied upon to conclude that Sertraline is safe for use in children and adolescents derives from clinical studies that were 10 to 52 weeks in duration and from the extrapolation of experience gained with adult patients. In particular, there are no studies that directly evaluate the effects of long-term Sertraline use on the growth, development, and maturation of children and adolescents. Do not take other medicines that contain Warfarin sodium while taking Warfarin sodium tablets. Each yellow, rectangle shaped, flat faced, beveled edge tablet imprinted with and 039 on one side and multi-scored on both sides contains 2 mg of Alprazolam, USP. Decreased clearance; use with caution. 1 137 See Hepatic Impairment under Dosage and Administration. Some Sertraline hydrochloride may pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking Sertraline hydrochloride tablets. Patients should be cautioned about the risk of serotonin syndrome with the concomitant use of SNRIs and SSRIs, including Sertraline hydrochloride, and triptans, tramadol, or other serotonergic agents. Toradol may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Toradol, especially in older adults. LaPorta LD. Sertraline-induced akathisia. J Clin Psychopharmacol. Ghose K. l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study.
Rosenblatt JE, Rosenblatt NC. How long a hiatus between discontinuing fluoxetine and beginning sertraline? Alprazolam. Data from in vitro studies of benzodiazepines other than Alprazolam suggest a possible drug interaction for the following: ergotamine, cyclosporine, amiodarone, nicardipine, and nifedipine. Prozac or other anti-depressants cause or intensify suicidality, FDA advisory committee determines. FDA Rep Prescrip OTC Pharmaceut. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Wort and with drugs that impair metabolism of serotonin in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue. The use of vitamin K 1 reduces response to subsequent Warfarin sodium therapy and patients may return to a pretreatment thrombotic status following the rapid reversal of a prolonged INR. Resumption of Warfarin sodium administration reverses the effect of vitamin K, and a therapeutic INR can again be obtained by careful dosage adjustment. If rapid re-anticoagulation is indicated, heparin may be preferable for initial therapy. Masand P, Gupta S, Dewan M. Suicidal ideation related to fluoxetine treatment. N Engl J Med. Feighner JP, Boyer WF, Tyler DL et al. Adverse consequences of fluoxetine-MAOI combination. J Clin Psychiatry. donepezil
SSRIs, including sertraline, may affect pupil size resulting in mydriasis; this effect may narrow the eye angle resulting in increased IOP and angle-closure glaucoma. 601 Use with caution in patients with angle-closure glaucoma or history of glaucoma. Use of psychoactive medication during pregnancy and possible effects on the fetus and newborn. Committee on Drugs. American Academy of Pediatrics. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, corn starch, docusate sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium benzoate. The Expert Consensus Panels for PTSD. The expert consensus guideline series: treatment of posttraumatic stress disorder. J Clin Psychiatry. Obsessive-compulsive disorder: Treatment of obsessions and compulsions in patients with obsessive-compulsive disorder OCD. Yonkers KA, Wisner KL, Stewart DE et al. The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists. Obstet Gynecol. For patients with a DVT or PE secondary to a transient reversible risk factor, treatment with Warfarin for 3 months is recommended. What should I tell my healthcare provider before taking Warfarin sodium tablets? Zyprexa is usually taken once a day. Olanzapine may be only part of a complete program of treatment that also includes counseling and other psychological support programs. Follow your doctor's instructions.
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Some patients may require an even slower dosage reduction. If intolerable symptoms occur, it is recommended to consider resuming the previously prescribed dose and to decrease the dose at a more gradual rate. See “ What is the most important information I should know about Warfarin sodium tablets? Wilson KL, Zelig CM, Harvey JP et al. Persistent pulmonary hypertension of the newborn is associated with mode of delivery and not with maternal use of selective serotonin reuptake inhibitors. Am J Perinatol.
In any case, reduction of dose must be undertaken under close supervision and must be gradual. If significant withdrawal symptoms develop, the previous dosing schedule should be reinstituted and, only after stabilization, should a less rapid schedule of discontinuation be attempted. In a controlled postmarketing discontinuation study of panic disorder patients which compared this recommended taper schedule with a slower taper schedule, no difference was observed between the groups in the proportion of patients who tapered to zero dose; however, the slower schedule was associated with a reduction in symptoms associated with a withdrawal syndrome.
The elderly may be more sensitive to the effects of benzodiazepines. They exhibit higher plasma Alprazolam concentrations due to reduced clearance of the drug as compared with a younger population receiving the same doses. Diamond S. The use of sumatriptan in patients on monoamine oxidase inhibitors. Neurology. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Support for the effectiveness of Alprazolam in the treatment of panic disorder came from three short-term, placebo-controlled studies up to 10 weeks in patients with diagnoses closely corresponding to DSM-III-R criteria for panic disorder. Toradol can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery coronary artery bypass graft, or CABG. While these events are generally self-limiting, there have been reports of serious discontinuation symptoms.